If every gun I owned carried only one cartridge in it's chamber I would be a happy man.
In today's freakin' insane society assigning some negative significance to every time they hear a balloon pop, I would relish their gaping mouths and wide-eyed stare that we shooters get the job done with one bullet at a time. After all, that's really what happens with all firearms, just with a much shorter dwell between ignitions. And the range of calibers and ballistic performance that can be realized by this simple break action pistol/rifle is almost unending. Yes, you must be conscious of pressures exceeding certain thresholds but I've found various wildcatters such as Reeder and Bellum assist on getting around those limitations. Hornady has also stepped up to the plate with their proprietary formulations of propellants and advanced design ballistics with new cartridges that perform unlike those of the past, ie. 6.8 SPC, 17 HMR. I can't wait for my next barrel and I don't even know what chamber it will have.