Doesn't make a lick of difference how accurate the rifle is, it only matters about the gun-and-shooter combo, and it only matters about how it's going to be used.

Sure one of my guns might be capable of .27MOA off a well-built bench, properly adjusted rests and calm air. The truth is that even using a good solid field rest on a regular day I'd be darn lucky to get it to shoot 0.5 MOA, and a more realistic expectation for a hasty set-up would be 1 MOA. And offhand, unsupported? Sheesh, I really can't depend on any better than about 9 MOA. Sure I can occasionally keep the shots in 4 MOA, but can you really depend on it, every time, on demand?
The fact is that for the vast majority of us, getting "stuck" with a 2.5 MOA gun won't make us shoot noticeably worse using field rests and at big game animals.