I am a true admirer of revolvers, and despite nearly 20 years of use of autopistols as service sidearms I still consider the revolver to be my "default setting" when it comes to an all-purpose shooting tool for short range hunting and close-quarters defense against predators--2 or 4 legged.
I have a pretty wide range of both autopistol and revolver calibers to choose from in the safe--22 LR through 45 Colt, with many stops in between those extremes. This occurred due to a pretty lively hobby interest in this field, and after 30-some years of shooting sidearms of all kinds--22 of these years as a police rangemaster--I have developed some opinions about what works and what doesn't--and there's lots more of the former than the latter.
One of those questions that makes its way to boards like this is "If you could only choose/own one handgun, what caliber and platform would it be?" I will immediately divide my response--two answers--by asking a question.....does the gun owner reload, or not?
If the shooter is also a reloader, my recommendation would be the 44 Magnum in a 4"-5" double action platform. The 44 Magnum in full-house loadings is a bit much for a lot of handgunners, but with load intensity control being exercised at the loading bench the rigors of adapting one's skills to the big bore revolver can be mollified greatly. The caliber has a wide range of bullet types available, lends itself readily to a wide range of powders, and is intrinsically VERY accurate. The caliber does fine work in the hunting fields, and is adaptable to defensive work through either 44 Special load usage or down-loaded Magnums.
If our shooter is not a reloader, I shift my thoughts to the 357 Magnum in 4"-5" barrelled double action flavor. This caliber has by far the widest availability of load types of any handgun caliber--from wadcutter target rounds to high-end hunting loads. A lot more folks can handle full-house 357 loads than they can the 44 caliber offerings of that intensity, and with judicious shot selection large game can be taken with this caliber.
As far as I'm concerned, the 357 Magnum has no peer as felon repellant--after adoption of the autopistol in 1987 in 9mm and 45 ACP, a few years later we brought on the 40 S&W and 357 Magnum. Since that time, I have always had a 4" 357 "on paper" along with my 45's. If I had to limit myself to one caliber for self-defense, it would be the 357 without a second thought. The effectiveness of the caliber out-weighs the tactical advantages offered by the autopistol platform, in my view. Had my agency offered the 357 option at the same time they expanded options to the autopistol, I would likely have changed only ammunition rather than platform type. I like it that much.