Welcome Howdy,
Why not? The soft lead may obturate enough for them to be reasonably accurate. If not, no big deal, but you'll never find out without trying them. Same goes for the HBWC. I have had revolvers in .38/.357 that liked them and others that wouldn't have anything accurate to do with them. Generally in a revolver, a RN design is more forgiving than a WC, though some really shine with WC's and mild loads of Bullseye.